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Image Search Results
Journal: Scientific Reports
Article Title: Modulation of the p75 neurotrophin receptor suppresses age-related basal forebrain cholinergic neuron degeneration
doi: 10.1038/s41598-019-41654-8
Figure Lengend Snippet: Diminished efficacy with shorter and later treatment. Five weeks of treatment once daily with 50 mg/kg LM11A-31 (n = 5) beginning at 17 months of age partially prevented and/or reversed the decrease in cholinergic neuron area in the MS and VDB seen in the vehicle treated mice (n = 4). Cholinergic neurons were identified by ChAT immunoreactivity and an unbiased estimate of area was obtained using Microbrightfield (MBF) software. A significant decrease in cell area measurements was seen in all groups (t-test, (n = 8) vs 18 months (n = 4), p values = 0.018–0.001). Inhibition and/or reversal of loss of cell size after five weeks of treatment was partial and reached significance only in the composite data for MS + VDB (t-test, treated vs vehicle, p = 0.032). Values are expressed as mean + sem.
Article Snippet: Sections were coded to reduce bias and
Techniques: Software, Inhibition